Chimeric rhesus monkeys study

Generation of Chimeric Rhesus Monkeys - ScienceDirect

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The ability to contribute to chimeric animals upon reintroduction into host embryos is the key feature of murine totipotent and pluripotent cells. Here, we demonstrate that rhesus monkey embryonic stem cells (ESCs) and isolated ICMs fail to incorporate into host embryos and develop into chimeras.

Generation of Chimeric Rhesus Monkeys - ScienceDirect

Generation of Chimeric Rhesus Monkeys

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1/20/2012 · Generation of Chimeric Rhesus Monkeys. ... These remarkably high pregnancy outcomes were not seen among other treatments in this study, or in our prior studies (Wolf et al., 2004). On average, pregnancy and implantation rates with non-manipulated rhesus embryos do not exceed 36% and 17%, respectively (Wolf et al., 2004). High pregnancy and ...

Generation of Chimeric Rhesus Monkeys

Evaluation of St. Louis encephalitis virus/dengue virus ...

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8/5/2008 · Replication and immunogenicity in rhesus monkeys. Two antigenic chimeric viruses, SLE/DEN4 clone 551 and SLE/DEN4Δ30 clone 545, were first selected for study in rhesus monkeys because they contained minimal adventitious mutations, which would enable an accurate assessment of the contribution of chimerization and the Δ30 mutation to ...

Evaluation of St. Louis encephalitis virus/dengue virus ...

Chimera (genetics) - Wikipedia

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A 1996 study found that such blood group chimerism is not rare. Another report of a human chimera was published in 1998, where a male human had some partially developed female organs due to chimerism. He had been conceived by in-vitro fertilization.

Chimera (genetics) - Wikipedia

Generation of Chimeric Rhesus Monkeys | Request PDF

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Generation of Chimeric Rhesus Monkeys. ... whereas offspring could not be produced using the inner cell mass and pluripotent cells in chimeric rhesus monkeys [20, 29]. In the present study, our ...

Generation of Chimeric Rhesus Monkeys | Request PDF

Chimeric Monkeys? Where Do We Go From Here? | Enhancing ...

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In research, scientists create chimeras in order to study how cells function. Mice chimeras are now commonplace in stem cell labs around the world. ... Caption: Chimero, a chimeric Rhesus monkey produced by aggregating six Rhesus blastocysts. Photo credit: OHSU. ... At the blastocyst stage, Rhesus monkeys don’t behave like mice. ...

Chimeric Monkeys? Where Do We Go From Here? | Enhancing ...

Generation of Chimeric Rhesus Monkeys: Cell

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The ability to contribute to chimeric animals upon reintroduction into host embryos is the key feature of murine totipotent and pluripotent cells. Here, we demonstrate that rhesus monkey embryonic stem cells (ESCs) and isolated ICMs fail to incorporate into host embryos and develop into chimeras.

Generation of Chimeric Rhesus Monkeys: Cell

Generation of Chimeric Rhesus Monkeys: Cell

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Generation of Chimeric Rhesus Monkeys. ... Drs. Richard Stouffer and Don Wolf for consulting, helpful discussions, and critical reading of the manuscript. This study was supported by startup funds from the Oregon National Primate Research Center and grants from the National Institutes of Health, HD057121, HD059946, HD063276, HD047675, HD018185 ...

Generation of Chimeric Rhesus Monkeys: Cell

World's first chimeric monkeys are born -- ScienceDaily

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1/5/2012 · The chimeric monkeys were born after the researchers essentially glued cells from separate rhesus monkey embryos together and successfully implanted these mixed embryos into mothers.

World's first chimeric monkeys are born -- ScienceDaily

World's First Three-Parent Chimeric Monkeys Created ...

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The world’s first chimeric monkeys were created in a laboratory last year, and they offer surprising new insights into embryonic stem cell therapy: One reason for often-poor treatment outcomes may be that we’re using embryos that are, strangely, just too old. Researchers have long been able to ...

World's First Three-Parent Chimeric Monkeys Created ...

World's first chimeric monkeys are born - Phys.org

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1/5/2012 · The chimeric monkeys were born after the researchers essentially glued cells from separate rhesus monkey embryos together and successfully implanted …

World's first chimeric monkeys are born - Phys.org

expert reaction to generation of chimeric rhesus monkeys ...

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“Chimeras are also frequently used in research to ask questions about gene function, and the type of chimera made in this study may also prove to be a valuable way to test whether this is conserved from mouse to monkey.” ‘Generation of Chimeric Rhesus Monkeys’ by Masahito Tachibana et al., published in Cell on Thursday 5th January 2012.

expert reaction to generation of chimeric rhesus monkeys ...

Meet Roku, Hex, and Chimero, the World’s First Chimeric ...

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1/6/2012 · Research shows major differences between mouse and primates in the behavior of early embryos toward introduced ESCs. Experiments leading to …

Meet Roku, Hex, and Chimero, the World’s First Chimeric ...

Protection of Rhesus Monkeys against Dengue Virus ...

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6/15/2006 · Rhesus monkeys develop viremia after dengue virus (DENV) inoculation and have been used as an animal model to study DENV infection and DENV vaccine candidates. We evaluated, in this model, the protective efficacy of a live attenuated tetravalent DENV vaccine (TDV) candidate against parenteral challenge with parental near-wild-type DENV strains.

Protection of Rhesus Monkeys against Dengue Virus ...

Evaluation of the Safety and Immunogenicity in Rhesus ...

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humans than mice. Indeed, rhesus monkeys have helped predict the subsequent human immunogenicities of various formulations of the P. falciparum malaria vaccine candidate RTS,S (11, 14, 28, 29). In the current study, we evaluated the safety and immunogenicity of the VMP001 vaccine in combi-nation with GLA-SE in rhesus monkeys. The vaccine formu-

Evaluation of the Safety and Immunogenicity in Rhesus ...

Immunoglobulin VH Usage during Primary Infection of Rhesus ...

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Rhesus Monkeys with Chimeric Simian-Human Immunodeficiency Viruses DAVID H. MARGOLIN,1* KEITH A. REIMANN,1 JOSEPH SODROSKI,2 GUNILLA B. KARLSSON,2 KLARA TENNER-RACZ,3 PAUL RACZ,3 AND NORMAN L ...

Immunoglobulin VH Usage during Primary Infection of Rhesus ...

Methods for creating transgenic primates | Lab Animal

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7/20/2016 · The first efforts at creating transgenic primates used delivery of a transgene through a lentiviral vector. In this method, viral genomes are modified to contain a gene of interest in place of ...

Methods for creating transgenic primates | Lab Animal

Chimeric macaques give new meaning to phrase, 'I'll be a ...

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1/5/2012 · Chimeric macaques give new meaning to phrase, 'I'll be a monkey's uncle' ... But the methods that work to create chimeric mice failed in rhesus monkeys, ... We need to study them in humans ...

Chimeric macaques give new meaning to phrase, 'I'll be a ...

Myelopoietin, an engineered chimeric IL-3 and G-CSF ...

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of engineered, chimeric molecules that bind and activate the IL-3 and G-CSF receptors on hematopoietic cells. This study investigated the in vivo hematopoi-etic response of rhesus monkeys admin-istered MPO after radiation-induced my-elosuppression. Animals were total body irradiated (TBI) in 2 series, with biologi-cally equivalent doses ...

Myelopoietin, an engineered chimeric IL-3 and G-CSF ...

The emergence and characterization of macrophage‐tropic ...

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The emergence and characterization of macrophage-tropic SIV/HIV chimeric viruses (SHIVs) present in CD4 T cell-depleted rhesus monkeys Tatsuhiko Igarashi,* Hiromi Imamichi,† Charles R. Brown,* Vanessa M. Hirsch,* and Malcolm A. Martin*,1 *Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; and ...

The emergence and characterization of macrophage‐tropic ...

Chimeric | definition of chimeric by Medical dictionary

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In another group of studies, the researchers have used several vaccine groups in rhesus monkeys infected with a chimeric HIV-SIV virus, known as SHIV. A non-replicating adenoviral vector as a …

Chimeric | definition of chimeric by Medical dictionary

Inhibition of costimulation allows for repeated systemic ...

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1/22/2004 · The study was carried out in rhesus monkeys (Macaca Mulatta). The animals met the following criteria: They were between 4 and 7 years of age, in …

Inhibition of costimulation allows for repeated systemic ...

Marmoset - Simple English Wikipedia, the free encyclopedia

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The marmosets are a group of New World monkeys. There are 22 marmoset species in four genera.All are in the biological family Callitrichidae.The term marmoset is also used in reference to the Goeldi's marmoset, Callimico goeldii, which is closely related.. Most marmosets are about 20 centimetres (8 in) long. Compared to other monkeys, they have some primitive features.

Marmoset - Simple English Wikipedia, the free encyclopedia

Evaluation of the safety and immuno genicity in rhesus ...

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27 novel chimeric recombinant protein VMP001 base d on the circumsporozoite protein (CSP) of P. ... In this study rhesus monkeys were 31 immunized intramuscularly three times with VMP 001 in combination with stable emulsion (SE), 32 or a synthetic TLR4 agonist (GLA) in …

Evaluation of the safety and immuno genicity in rhesus ...

Monkey Embryo Mashup Results In First Primate Chimeras ...

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Scientists have produced the world's first chimeric monkeys, developed from stem cells harvested from separate embryos. They contain genetic material from as many as six genomes. The infant rhesus ...

Monkey Embryo Mashup Results In First Primate Chimeras ...

Limited Contribution of Humoral Immunity to the Clearance ...

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9/1/2004 · Depletion of CD20 + and CD8 + lymphocytes in peripheral blood from rhesus monkeys, by intravenous infusion of the monoclonal mouse/human chimeric anti-human CD20 antibody (Rituxan) alone or with monoclonal mouse/human chimeric anti-CD8 antibody (cM-T807). Infusion of the control monoclonal antibody (MAb) had no effect on the number of CD20 + or CD8 + lymphocytes in …

Limited Contribution of Humoral Immunity to the Clearance ...

(PDF) Left gaze bias in humans, rhesus monkeys and ...

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18 19 Experiment 2: LGB in rhesus monkeys and domestic dogs: phylogenetic study 20 To address the question of whether a face-specific LGB is restricted to human or to 21 primate species, or whether it is perhaps found more extensively among species living in 22 complex social environments, we examined the responses of rhesus monkeys (Macaca 23 ...

(PDF) Left gaze bias in humans, rhesus monkeys and ...

Transgenic rhesus monkeys produced by gene transfer into ...

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10/12/2010 · The development of transgenic technologies in monkeys is important for creating valuable animal models of human physiology so that the etiology of diseases can be studied and potential therapies for their amelioration may be developed. However, the efficiency of producing transgenic primate animals is presently very low, and there are few reports of success.

Transgenic rhesus monkeys produced by gene transfer into ...

Baby Monkeys with 6 Genomes Are Scientific First ...

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1/6/2012 · They look like ordinary baby rhesus macaques, but Hex, Roku and Chimero are the world's first chimeric monkeys, each with cells from the genomes of as many as six rhesus monkeys. Until now ...

Baby Monkeys with 6 Genomes Are Scientific First ...

In vivo treatment with a monoclonal chimeric anti-CD4 ...

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Therefore, the chimpanzee was chosen as an animal rheumatoid arthritis (RA) patients in the clinic [6-8] From species to determine the effects of treatment with chimeric M- studies in rhesus monkeys which were treated with murine anti- T412 on the CD4 cells and the effects on the immune response.

In vivo treatment with a monoclonal chimeric anti-CD4 ...

Control of Viremia and Prevention of Clinical AIDS in ...

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10/20/2000 · In the 15 rhesus monkeys included in this study that expressed the major histocompatibility complex (MHC) ... This virus was derived by in vivo passage of SHIV-89.6, a chimeric virus consisting of the SIVmac239 backbone and the HIV-1 89.6 envelope gene, which was cloned from a primary patient R5/X4 dual-tropic HIV-1 isolate .

Control of Viremia and Prevention of Clinical AIDS in ...

Theologyplus

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Chimeric Monkeys? Where Do We Go From Here? January 5, 2012 Ron Cole-Turner Leave a comment. ... scientists create chimeras in order to study how cells function. Mice chimeras are now commonplace in stem cell labs around the world. ... Caption: Chimero, a chimeric Rhesus monkey produced by aggregating six Rhesus blastocysts. Photo credit: OHSU.

Theologyplus

Rhesus Monkeys - Cancer Research

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human chimeric antibodies (16) containing the variable region of the ... In this study, we initially constructed two chimeric antibodies of human IgGl and IgG3 isotypes from the murine ABL 364 and ... compared with that of the parent murine antibody in rhesus monkeys. It

Rhesus Monkeys - Cancer Research

Effects of fenofibrate on lipid parameters in obese rhesus ...

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mg/kg was originally planned for this study; however, it was found to require an unacceptably large amount of vehicle for delivery. Thus, it was decided to continue for an additional 4 ®. (. Effects of fenofibrate on lipid parameters in obese rhesus monkeys fenofibrate.

Effects of fenofibrate on lipid parameters in obese rhesus ...

Marmoset - Wikipedia

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The marmosets, (/ ˈ m ɑːr m ə ˌ z ɛ t s, -ˌ s ɛ t s /), also known as zaris, are twenty-two New World monkey species of the genera Callithrix, Cebuella, Callibella and Mico.All four genera are part of the biological family Callitrichidae.The term marmoset is also used in reference to the Goeldi's marmoset, Callimico goeldii, which is closely related.

Marmoset - Wikipedia
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